Pro-neuroinflammatory and neurotoxic potential of extracellular histones H1 and H3

Pro-neuroinflammatory and neurotoxic potential of extracellular histones H1 and H3

Histones organize DNA within cellular nuclei, but they can be released from damaged cells. In peripheral tissues extracellular histones act as damage-associated molecular patterns (DAMPs) inducing pro-inflammatory activation of immune cells. Limited studies have considered DAMP-like activity of hist...

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Bibliographic Details
Main Authors: Seamus A. McRae, Christy M. Richards, Dylan E. Da Silva, Ishvin Riar, Sijie (Shirley) Yang, Noah E. Zurfluh, Julien Gibon, Andis Klegeris
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Neuroscience Research
Subjects:
Cytokines
DAMPs
Microglia
Neurodegenerative diseases
Neuroinflammation
Neurotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0168010224000087

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http://www.sciencedirect.com/science/article/pii/S0168010224000087

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