Genetic Implication of Specific Glutamatergic Neurons of the Prefrontal Cortex in the Pathophysiology of Schizophrenia

Genetic Implication of Specific Glutamatergic Neurons of the Prefrontal Cortex in the Pathophysiology of Schizophrenia

Background: The prefrontal cortex (PFC) has been strongly implicated in the pathophysiology of schizophrenia. Here, we combined high-resolution single-nuclei RNA sequencing data from the human PFC with large-scale genomic data for schizophrenia to identify constituent cell populations likely to medi...

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Bibliographic Details
Main Authors: Claire E. Tume, Sophie L. Chick, Peter A. Holmans, Elliott Rees, Michael C. O’Donovan, Darren Cameron, Nicholas J. Bray
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Biological Psychiatry Global Open Science
Subjects:
Gene expression
Genetic
Genome-wide association study (GWAS)
Prefrontal cortex
Rare variant
Schizophrenia
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174324000582

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http://www.sciencedirect.com/science/article/pii/S2667174324000582

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