Evaluation of AMG510 Therapy on <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer and Colorectal Cancer Cell Using a 3D Invasive Tumor Spheroid System under Normoxia and Hypoxia

Evaluation of AMG510 Therapy on <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer and Colorectal Cancer Cell Using a 3D Invasive Tumor Spheroid System under Normoxia and Hypoxia

A 3D tumor spheroid has been increasingly applied in pharmaceutical development for its simulation of the tumor structure and microenvironment. The embedded-culture of a tumor spheroid within a hydrogel microenvironment could help to improve the mimicking of in vivo cell growth and the development o...

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Bibliographic Details
Main Authors: Meng Huang, Wei Hou, Jing Zhang, Menglan Li, Zilin Zhang, Xiaoran Li, Zaozao Chen, Cailian Wang, Lihua Yang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Bioengineering
Subjects:
spheroid
invasion
imaging
AMG510
<i>KRAS</i>
non–small cell lung cancer
Online Access:https://www.mdpi.com/2306-5354/9/12/792

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https://www.mdpi.com/2306-5354/9/12/792

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