Production of Highly Active Recombinant Dermonecrotic Toxin of <i>Bordetella Pertussis</i>

Production of Highly Active Recombinant Dermonecrotic Toxin of <i>Bordetella Pertussis</i>

Pathogenic <i>Bordetella</i> bacteria release a neurotropic dermonecrotic toxin (DNT) that is endocytosed into animal cells and permanently activates the Rho family GTPases by polyamination or deamidation of the glutamine residues in their switch II regions (e.g., Gln63 of RhoA). DNT was...

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Bibliographic Details
Main Authors: Ondrej Stanek, Irena Linhartova, Jana Holubova, Ladislav Bumba, Zdenko Gardian, Anna Malandra, Barbora Bockova, Shihono Teruya, Yasuhiko Horiguchi, Radim Osicka, Peter Sebo
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Toxins
Subjects:
Bordetella
GTPase
deamidation
dermonecrotic toxin
recombinant
electron microscopy
Online Access:https://www.mdpi.com/2072-6651/12/9/596

Internet

https://www.mdpi.com/2072-6651/12/9/596

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