Pre-existing subclones determine radioresistance in rectal cancer organoids

Pre-existing subclones determine radioresistance in rectal cancer organoids

Summary: More than half of all patients with cancer receive radiation therapy, but resistance is commonly observed. Currently, it is unknown whether resistance to radiation therapy is acquired or inherently present. Here, we employed organoids derived from rectal cancer and single-cell whole-genome...

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Bibliographic Details
Main Authors: Daan Andel, Bas Jeroen Viergever, Niek Alexander Peters, Danielle Adriana Elisabeth Raats, Susanne Jolien Schenning-van Schelven, Martijn Peter Willem Intven, Maurice Zandvliet, Jeroen Hagendoorn, Inne Hilbrand Max Borel Rinkes, Onno Kranenburg
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724000639

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http://www.sciencedirect.com/science/article/pii/S2211124724000639

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