Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Sphingosine kinase (SphK) converts sphingosine into lipids, and is implicated in inflammation. Here the authors show that SphK1 functions as an acetyltransferase, regulates microglial phagocytosis and is reduced in a model of Alzheimer’s Disease, such that its restoration ameliorates pathology

Bibliographic Details
Main Authors: Ju Youn Lee, Seung Hoon Han, Min Hee Park, Bosung Baek, Im-Sook Song, Min-Koo Choi, Yoh Takuwa, Hoon Ryu, Seung Hyun Kim, Xingxuan He, Edward H. Schuchman, Jae-Sung Bae, Hee Kyung Jin
Format: Article
Language:English
Published: Nature Portfolio 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03674-2

Internet

https://doi.org/10.1038/s41467-018-03674-2

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