PRPS2 mutations drive acute lymphoblastic leukemia relapse through influencing PRPS1/2 hexamer stability

PRPS2 mutations drive acute lymphoblastic leukemia relapse through influencing PRPS1/2 hexamer stability

Tumor relapse is the major cause of treatment failure in childhood acute lymphoblastic leukemia (ALL), yet the underlying mechanisms are still elusive. Here, we demonstrate that phosphoribosyl pyrophosphate synthetase 2 (PRPS2) mutations drive ALL relapse through influencing PRPS1/2 hexamer stabilit...

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Bibliographic Details
Main Authors: Lili Song, Peifeng Li, Huiying Sun, Lixia Ding, Jing Wang, Benshang Li, Bin-Bing S. Zhou, Haizhong Feng, Yanxin Li
Format: Article
Language:English
Published: Wolters Kluwer Health 2023-03-01
Series:Blood Science
Online Access:http://journals.lww.com/10.1097/BS9.0000000000000139

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http://journals.lww.com/10.1097/BS9.0000000000000139

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