Kumatakenin inhibited iron-ferroptosis in epithelial cells from colitis mice by regulating the Eno3-IRP1-axis

Kumatakenin inhibited iron-ferroptosis in epithelial cells from colitis mice by regulating the Eno3-IRP1-axis

Inhibition of epithelial ferroptosis in colonic tissues relieved clinical symptoms and improved endoscopic presentations in inflammatory bowel disease (IBD). Kumatakenin, the main ingredient of traditional Chinese medicinal cloves and Alpinia purpurata, is reported to possess therapeutic benefits. H...

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Bibliographic Details
Main Authors: Arenbaoligao, Xinrui Guo, Jiahao Xiong, Shuangshuang Zhang, Yuewen Yang, Dapeng Chen, Yu Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
kumatakenin
colitis
ferroptosis
iron level
ENO3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1127931/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1127931/full

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