Computational Insights into the Allosteric Modulation of a Phthalate-Degrading Hydrolase by Distal Mutations

Computational Insights into the Allosteric Modulation of a Phthalate-Degrading Hydrolase by Distal Mutations

Phthalate esters (PAEs) are a ubiquitous kind of environmental endocrine that disrupt chemicals, causing environmental and health issues. EstJ6 is an effective phthalate-degrading hydrolase, and its mutant with a combination of three non-conservative distal mutations has an improved activity against...

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Bibliographic Details
Main Authors: Ran Xu, Yiqiong Bao, Mengrong Li, Yan Zhang, Lili Xi, Jingjing Guo
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomolecules
Subjects:
esterases
phthalate esters
rational design of proteins
distal mutations
molecular dynamics simulation
toxicity
Online Access:https://www.mdpi.com/2218-273X/13/3/443

Internet

https://www.mdpi.com/2218-273X/13/3/443

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