A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

Abstract In the context of continuous emergence of SARS-CoV-2 variants of concern (VOCs), one strategy to prevent the severe outcomes of COVID-19 is developing safe and effective broad-spectrum vaccines. Here, we present preclinical studies of a RBD vaccine derived from the Gamma SARS-CoV-2 variant...

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Main Authors: Lorena M. Coria, Juan Manuel Rodriguez, Agostina Demaria, Laura A. Bruno, Mayra Rios Medrano, Celeste Pueblas Castro, Eliana F. Castro, Sabrina A. Del Priore, Andres C. Hernando Insua, Ingrid G. Kaufmann, Lucas M. Saposnik, William B. Stone, Lineia Prado, Ulises S. Notaro, Ayelen N. Amweg, Pablo U. Diaz, Martin Avaro, Hugo Ortega, Ana Ceballos, Valeria Krum, Francisco M. Zurvarra, Johanna E. Sidabra, Ignacio Drehe, Jonathan A. Baqué, Mariana Li Causi, Analia V. De Nichilo, Cristian J. Payes, Teresa Southard, Julio C. Vega, Albert J. Auguste, Diego E. Álvarez, Juan M. Flo, Karina A. Pasquevich, Juliana Cassataro
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45180-8

Internet

https://doi.org/10.1038/s41467-024-45180-8

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