MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease

MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease

Abstract Background Matrix metallopeptidase 9 (MMP9) has been implicated in a variety of neurological disorders, including Alzheimer’s disease (AD), where MMP9 levels are elevated in the brain and cerebrovasculature. Previously our group demonstrated apolipoprotein E4 (apoE4) was less efficient in r...

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Bibliographic Details
Main Authors: Charis Ringland, Jonas Elias Schweig, Maxwell Eisenbaum, Daniel Paris, Ghania Ait-Ghezala, Michael Mullan, Fiona Crawford, Laila Abdullah, Corbin Bachmeier
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Neuroscience
Subjects:
Alzheimer’s disease
Matrix metallopeptidase 9
Apolipoprotein E
Social recognition memory
Beta-amyloid
Online Access:https://doi.org/10.1186/s12868-021-00643-2

Internet

https://doi.org/10.1186/s12868-021-00643-2

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