MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease

MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease

Abstract Background Matrix metallopeptidase 9 (MMP9) has been implicated in a variety of neurological disorders, including Alzheimer’s disease (AD), where MMP9 levels are elevated in the brain and cerebrovasculature. Previously our group demonstrated apolipoprotein E4 (apoE4) was less efficient in r...

Full description

Bibliographic Details
Main Authors: Charis Ringland, Jonas Elias Schweig, Maxwell Eisenbaum, Daniel Paris, Ghania Ait-Ghezala, Michael Mullan, Fiona Crawford, Laila Abdullah, Corbin Bachmeier
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Neuroscience
Subjects:
Alzheimer’s disease
Matrix metallopeptidase 9
Apolipoprotein E
Social recognition memory
Beta-amyloid
Online Access:https://doi.org/10.1186/s12868-021-00643-2

Similar Items

Similar Items