Interaction of 2′R-ochratoxin A with Serum Albumins: Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells

Interaction of 2′R-ochratoxin A with Serum Albumins: Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells

Ochratoxin A (OTA) is a nephrotoxic mycotoxin. Roasting of OTA-contaminated coffee results in the formation of 2′R-ochratoxin A (2′R-OTA), which appears in the blood of coffee drinkers. Human serum albumin (HSA) binds 2′R-OTA (and OTA) with high affinity; therefore, alb...

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Bibliographic Details
Main Authors: Zelma Faisal, Diána Derdák, Beáta Lemli, Sándor Kunsági-Máté, Mónika Bálint, Csaba Hetényi, Rita Csepregi, Tamás Kőszegi, Franziska Sueck, Benedikt Cramer, Hans-Ulrich Humpf, Miklós Poór
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Toxins
Subjects:
2′R-ochratoxin A
ochratoxin A
serum albumin
albumin-ligand interaction
species differences
cellular toxicity
Online Access:http://www.mdpi.com/2072-6651/10/9/353

Internet

http://www.mdpi.com/2072-6651/10/9/353

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