Low-affinity CTCF binding drives transcriptional regulation whereas high-affinity binding encompasses architectural functions

Low-affinity CTCF binding drives transcriptional regulation whereas high-affinity binding encompasses architectural functions

Summary: CTCF is a DNA-binding protein which plays critical roles in chromatin structure organization and transcriptional regulation; however, little is known about the functional determinants of different CTCF-binding sites (CBS). Using a conditional mouse model, we have identified one set of CBSs...

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Bibliographic Details
Main Authors: Ester Marina-Zárate, Ana Rodríguez-Ronchel, Manuel J. Gómez, Fátima Sánchez-Cabo, Almudena R. Ramiro
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:iScience
Subjects:
Molecular Structure
Molecular mechanism of gene regulation
Components of the immune system
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223001839

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http://www.sciencedirect.com/science/article/pii/S2589004223001839

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