Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9).

Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9).

Late-onset non-syndromic autosomal dominant hearing loss 9 (DFNA9) is a hearing impairment caused by mutations in the coagulation factor C homology gene (COCH). COCH encodes for cochlin, a major component of the cochlear extracellular matrix. Though biochemical and genetic studies have characterized...

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Bibliographic Details
Main Authors: Tomoko Honda, Norihito Kawasaki, Rei Yanagihara, Ryo Tamura, Karin Murakami, Tomomi Ichimiya, Naoki Matsumoto, Shoko Nishihara, Kazuo Yamamoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0268485

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https://doi.org/10.1371/journal.pone.0268485

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