The Dual Role of the Innate Immune System in the Effectiveness of mRNA Therapeutics

The Dual Role of the Innate Immune System in the Effectiveness of mRNA Therapeutics

Advances in molecular biology have revolutionized the use of messenger RNA (mRNA) as a therapeutic. The concept of nucleic acid therapy with mRNA originated in 1990 when Wolff et al. reported successful expression of proteins in target organs by direct injection of either plasmid DNA or mRNA. It too...

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Bibliographic Details
Main Authors: Albert Muslimov, Valeriy Tereshchenko, Daniil Shevyrev, Anna Rogova, Kirill Lepik, Vasiliy Reshetnikov, Roman Ivanov
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
mRNA
innate immunity
NF-κB
PAMP
DAMP
cGAS/STING
Online Access:https://www.mdpi.com/1422-0067/24/19/14820

Internet

https://www.mdpi.com/1422-0067/24/19/14820

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