TRIAC disrupts cerebral thyroid hormone action via negative feedback and heterogenous distribution among organs

TRIAC disrupts cerebral thyroid hormone action via negative feedback and heterogenous distribution among organs

Summary: As 3,3′,5-triiodothyroacetic acid (TRIAC), a metabolite of thyroid hormones (THs), was previously detected in sewage effluent, we aimed to investigate exogenous TRIAC’s potential for endocrine disruption. We administered either TRIAC or 3,3′,5-triiodo-L-thyronine (LT3) to euthyroid mice and...

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Bibliographic Details
Main Authors: Ichiro Yamauchi, Takuro Hakata, Yohei Ueda, Taku Sugawa, Ryo Omagari, Yasuo Teramoto, Shoji F. Nakayama, Daisuke Nakajima, Takuya Kubo, Nobuya Inagaki
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Chemical substance
Endocrine disrupter
Biochemistry
Endocrine system physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223012129

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http://www.sciencedirect.com/science/article/pii/S2589004223012129

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