Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting

Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting

Reading frame maintenance is critical for accurate translation. We show that the conserved eukaryotic/archaeal protein Mbf1 acts with ribosomal proteins Rps3/uS3 and eukaryotic Asc1/RACK1 to prevent frameshifting at inhibitory CGA-CGA codon pairs in the yeast Saccharomyces cerevisiae. Mutations in R...

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Bibliographic Details
Main Authors: Jiyu Wang, Jie Zhou, Qidi Yang, Elizabeth J Grayhack
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
translation
frameshifting
ribosome
Rps3
Asc1/RACK1
Mbf1
Online Access:https://elifesciences.org/articles/39637

Internet

https://elifesciences.org/articles/39637

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