TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model

TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model

IntroductionAlzheimer’s disease (AD) is marked by the accumulation of fibrillary aggregates composed of pathological tau protein. Although neuroinflammation is frequently observed in conjunction with tau pathology, current preclinical evidence does not sufficiently establish a direct causal role in...

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Bibliographic Details
Main Authors: Neha Basheer, Muhammad Khalid Muhammadi, Carlos Leandro Freites, Martin Avila, Miraj Ud Din Momand, Natalia Hryntsova, Tomas Smolek, Stanislav Katina, Norbert Zilka
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
neuroinflammation
tau
lipopolysaccharide
phosphorylation
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1468602/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2024.1468602/full

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