Altered metabolic connectivity within the limbic cortico-striato-thalamo-cortical circuit in presymptomatic and symptomatic behavioral variant frontotemporal dementia

Altered metabolic connectivity within the limbic cortico-striato-thalamo-cortical circuit in presymptomatic and symptomatic behavioral variant frontotemporal dementia

Abstract Background Behavioral variant frontotemporal dementia (bvFTD) is predominantly considered a dysfunction in cortico-cortical transmission, with limited direct investigation of cortical-subcortical transmission. Thus, we aimed to characterize the metabolic connectivity between areas of the li...

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Bibliographic Details
Main Authors: Li Liu, Min Chu, Binbin Nie, Deming Jiang, Kexin Xie, Yue Cui, Lin Liu, Yu Kong, Zhongyun Chen, Haitian Nan, Pedro Rosa-Neto, Liyong Wu
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Frontotemporal dementia
MAPT gene
Metabolic connectivity
Striatum
Cortico-striato-thalamic-cortical (CSTC) circuit
Online Access:https://doi.org/10.1186/s13195-022-01157-7

Internet

https://doi.org/10.1186/s13195-022-01157-7

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