Modelling genetic stability in engineered cell populations

Abstract Predicting the evolution of engineered cell populations is a highly sought-after goal in biotechnology. While models of evolutionary dynamics are far from new, their application to synthetic systems is scarce where the vast combination of genetic parts and regulatory elements creates a uniq...

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Bibliographic Details
Main Authors: Duncan Ingram, Guy-Bart Stan
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38850-6