New oxindole carboxamides as inhibitors of DENV NS5 RdRp: Design, synthesis, docking and Biochemical characterization

New oxindole carboxamides as inhibitors of DENV NS5 RdRp: Design, synthesis, docking and Biochemical characterization

Dengue is a mosquito-borne disease caused by the dengue virus belonging to family flaviviridae and has grown to be a major global public health issue. Despite decades of effort, the global comeback of dengue is evidence of the inadequacy of present management techniques. Due to the loss of healthy l...

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Bibliographic Details
Main Authors: Chandra Prakash Koraboina, Parameswari Akshinthala, Naresh Kumar Katari, Ravi Adarasandi, Sreekantha Babu Jonnalagadda, Rambabu Gundla
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
Dengue virus
Oxindoline carboxamide derivatives
RNA dependent RNA polymerase
Molecular docking
SPR binding analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023087182

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http://www.sciencedirect.com/science/article/pii/S2405844023087182

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