Selecting Genetic Variants and Interactions Associated with Amyotrophic Lateral Sclerosis: A Group LASSO Approach

Selecting Genetic Variants and Interactions Associated with Amyotrophic Lateral Sclerosis: A Group LASSO Approach

Amyotrophic lateral sclerosis (ALS) is a multi-system neurodegenerative disease that affects both upper and lower motor neurons, resulting from a combination of genetic, environmental, and lifestyle factors. Usually, the association between single-nucleotide polymorphisms (SNPs) and this disease is...

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Bibliographic Details
Main Authors: Sofia Galvão Feronato, Maria Luiza Matos Silva, Rafael Izbicki, Ticiana D. J. Farias, Patrícia Shigunov, Bruno Dallagiovanna, Fabio Passetti, Hellen Geremias dos Santos
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Journal of Personalized Medicine
Subjects:
amyotrophic lateral sclerosis
genome-wide association studies
group LASSO regularization
single-nucleotide polymorphisms
pairwise interaction
Online Access:https://www.mdpi.com/2075-4426/12/8/1330

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https://www.mdpi.com/2075-4426/12/8/1330

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