Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma

Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma

Background and aimsThe key role of tissue-resident memory T (TRM) cells in the immune regulation of hepatocellular carcinoma (HCC) has been investigated and reported, but the regulatory mechanism of tumor microenvironment on TRM cells is still unclear. Lymphocyte activating gene 3 (LAG-3) is a promi...

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Bibliographic Details
Main Authors: Changjie Yang, Qiwei Qian, Yudong Zhao, Bingyuan Huang, Ruilin Chen, Qiyu Gong, Hao Ji, Chenchen Wang, Lei Xia, Zhengrui You, Jianjun Zhang, Xiaosong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
hepatocellular carcinoma
tissue-resident memory T cells
lymphocyte activation gene 3
exhaustion
granzyme B
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1112672/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1112672/full

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