Seropositivity-Dependent Association between LINE-1 Methylation and Response to Methotrexate Therapy in Early Rheumatoid Arthritis Patients

Seropositivity-Dependent Association between LINE-1 Methylation and Response to Methotrexate Therapy in Early Rheumatoid Arthritis Patients

Background: Methotrexate (MTX) is considered the first choice among disease-modifying anti-rheumatic drugs (DMARDs) for rheumatoid arthritis (RA) treatment. However, response to it varies as approximately 40% of the patients do not respond and would lose the most effective period of treatment time....

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Bibliographic Details
Main Authors: Amin Ravaei, Lia Pulsatelli, Elisa Assirelli, Riccardo Meliconi, Jacopo Ciaffi, Elisa Gremese, Barbara Tolusso, Carlo Salvarani, Marcello Govoni, Michele Rubini
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Genes
Subjects:
rheumatoid arthritis
LINE-1
DNA methylation
methotrexate
biomarkers
rheumatoid factor
Online Access:https://www.mdpi.com/2073-4425/13/11/2012

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https://www.mdpi.com/2073-4425/13/11/2012

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