Specific DNAzymes cleave the 300–618 nt of 5′UTR to inhibit DHAV-1 translation and replication

Specific DNAzymes cleave the 300–618 nt of 5′UTR to inhibit DHAV-1 translation and replication

DNAzymes effectively inhibit the expression of viral genes. Duck hepatitis A virus type-1 (DHAV-1) genomic RNA carries an internal ribosome entry site (IRES). The IRES initiates the translation of DHAV-1 via a mechanism that differs from that of cap-dependent translation. Therefore, it is an attract...

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Bibliographic Details
Main Authors: Yanglin Li, Ling Wei, Anchun Cheng, Mingshu Wang, Xumin Ou, Sai Mao, Bin Tian, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Qun Gao, Di Sun, Xinxin Zhao, Renyong Jia, Mafeng Liu, Dekang Zhu, Shun Chen, Yanling Yu, Ling Zhang, Leichang Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Microbiology
Subjects:
duck hepatitis A virus type 1
the 300–618 nt of 5′UTR
DNAzyme
DZ454
cleavage
inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1064612/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.1064612/full

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