Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas

Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas

P66Shc and Rac1 proteins are responsible for tumor-associated inflammation, particularly in brain tumors characterized by elevated oxidative stress and increased reactive oxygen species (ROS) production. Quercetin, a natural polyphenolic flavonoid, is a well-known redox modulator with anticancer pro...

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Bibliographic Details
Main Authors: Rafia A. Baba, Hilal A. Mir, Taseem A. Mokhdomi, Hina F. Bhat, Ajaz Ahmad, Firdous A. Khanday
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
quercetin
ROS
cell proliferation
cell migration
P66shc
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1318797/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1318797/full

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