Effect of Hypoxia in the Transcriptomic Profile of Lung Fibroblasts from Idiopathic Pulmonary Fibrosis

Effect of Hypoxia in the Transcriptomic Profile of Lung Fibroblasts from Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease characterized by exacerbated extracellular matrix deposition that disrupts oxygen exchange. Hypoxia and its transcription factors (HIF-1α and 2α) influence numerous circuits that could perpetuate fibrosis by increasing myofibroblasts...

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Bibliographic Details
Main Authors: Yair Romero, Yalbi Itzel Balderas-Martínez, Miguel Angel Vargas-Morales, Manuel Castillejos-López, Joel Armando Vázquez-Pérez, Jazmín Calyeca, Luz María Torres-Espíndola, Nelly Patiño, Angel Camarena, Ángeles Carlos-Reyes, Edgar Flores-Soto, Guadalupe León-Reyes, Martha Patricia Sierra-Vargas, Iliana Herrera, Erika Rubí Luis-García, Víctor Ruiz, Rafael Velázquez-Cruz, Arnoldo Aquino-Gálvez
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
hypoxia inducible factors
microarray
IPF fibroblasts
Online Access:https://www.mdpi.com/2073-4409/11/19/3014

Internet

https://www.mdpi.com/2073-4409/11/19/3014

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