In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model

In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model

Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by components of innate immunity, which limit their therapeutic capacity and can potentially lead to adverse side effects. IONPs were previously...

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Bibliographic Details
Main Authors: Alexandra Gerogianni, Melissa Bal, Camilla Mohlin, Trent M. Woodruff, John D. Lambris, Tom E. Mollnes, Dick J. Sjöström, Per H. Nilsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
thromboinflammation
iron oxide nanoparticles
endothelial cells
complement activation
complement inhibition
whole blood
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1101387/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1101387/full

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