Magnitude of Off-Target Allo-HLA Reactivity by Third-Party Donor-Derived Virus-Specific T Cells Is Dictated by HLA-Restriction

Magnitude of Off-Target Allo-HLA Reactivity by Third-Party Donor-Derived Virus-Specific T Cells Is Dictated by HLA-Restriction

T-cell products derived from third-party donors are clinically applied, but harbor the risk of off-target toxicity via induction of allo-HLA cross-reactivity directed against mismatched alleles. We used third-party donor-derived virus-specific T cells as model to investigate whether virus-specificit...

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Bibliographic Details
Main Authors: Wesley Huisman, Didier A. T. Leboux, Lieve E. van der Maarel, Lois Hageman, Derk Amsen, J. H. Frederik Falkenburg, Inge Jedema
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
virus-specific T cells
allo-HLA cross-reactivity
adoptive T cell immunotherapy
HLA-mismatched donor
cytotoxic T cells
Graft Versus Host Disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.630440/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.630440/full

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