Magnitude of Off-Target Allo-HLA Reactivity by Third-Party Donor-Derived Virus-Specific T Cells Is Dictated by HLA-Restriction

Magnitude of Off-Target Allo-HLA Reactivity by Third-Party Donor-Derived Virus-Specific T Cells Is Dictated by HLA-Restriction

T-cell products derived from third-party donors are clinically applied, but harbor the risk of off-target toxicity via induction of allo-HLA cross-reactivity directed against mismatched alleles. We used third-party donor-derived virus-specific T cells as model to investigate whether virus-specificit...

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Bibliographic Details
Main Authors:	Wesley Huisman, Didier A. T. Leboux, Lieve E. van der Maarel, Lois Hageman, Derk Amsen, J. H. Frederik Falkenburg, Inge Jedema
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Immunology
Subjects:	virus-specific T cells allo-HLA cross-reactivity adoptive T cell immunotherapy HLA-mismatched donor cytotoxic T cells Graft Versus Host Disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.630440/full

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