Treponema pallidum protein Tp0136 promoting MMPs/TIMPs imbalance via PI3K, MAPK and NF-κB signalling pathways in HDVSMCs

Treponema pallidum protein Tp0136 promoting MMPs/TIMPs imbalance via PI3K, MAPK and NF-κB signalling pathways in HDVSMCs

The invasive capability of Treponema. pallidum is central to its infection process. Matrix metalloproteinases (MMPs), which are specifically inhibited by the tissue inhibitors of metalloproteinases (TIMPs), play a pivotal role in promoting pathogenic invasion by destroying tissue barriers within the...

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Bibliographic Details
Main Authors: Chun-Xiang Cai, Shu-Lian Li, Hui-Ling Lin, Zi-Han Wei, Lin Xie, Li-Rong Lin, Jian-Jun Niu, Tian-Ci Yang
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Heliyon
Subjects:
Treponema pallidum
Vascular smooth muscle cells
Matrix metalloproteinases
Tissue inhibitors of metalloproteinases
Imbalance
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022033539

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http://www.sciencedirect.com/science/article/pii/S2405844022033539

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