Immunization of pigs with replication-incompetent adenovirus-vectored African swine fever virus multi-antigens induced humoral immune responses but no protection following contact challenge

Immunization of pigs with replication-incompetent adenovirus-vectored African swine fever virus multi-antigens induced humoral immune responses but no protection following contact challenge

IntroductionAfrican swine fever virus (ASFV) is a pathogen of great economic importance given that continues to threaten the pork industry worldwide, but there is no safe vaccine or treatment available. Development of a vaccine is feasible as immunization of pigs with some live attenuated ASFV vacci...

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Bibliographic Details
Main Authors: Michelle D. Zajac, Jessie D. Trujillo, Jianxiu Yao, Rakshith Kumar, Neha Sangewar, Shehnaz Lokhandwala, Huldah Sang, Kylynn Mallen, Jayden McCall, Leeanna Burton, Deepak Kumar, Emily Heitmann, Tristan Burnum, Suryakant D. Waghela, Kelli Almes, Juergen Richt, Tae Kim, Waithaka Mwangi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Veterinary Science
Subjects:
African swine fever (ASFV)
polyvalent Ad5 vectored vaccine
natural transmission model
histopathology
real-time quantitative polymerase chain reaction (RT-qPCR)
IgG
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2023.1208275/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2023.1208275/full

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