Genome-wide screening identified SEC61A1 as an essential factor for mycolactone-dependent apoptosis in human premonocytic THP-1 cells.

Genome-wide screening identified SEC61A1 as an essential factor for mycolactone-dependent apoptosis in human premonocytic THP-1 cells.

Buruli ulcer is a chronic skin disease caused by a toxic lipid mycolactone produced by Mycobacterium ulcerans, which induces local skin tissue destruction and analgesia. However, the cytotoxicity pathway induced by mycolactone remains largely unknown. Here we investigated the mycolactone-induced cel...

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Bibliographic Details
Main Authors: Akira Kawashima, Mitsuo Kiriya, Junichiro En, Kazunari Tanigawa, Yasuhiro Nakamura, Yoko Fujiwara, Yuqian Luo, Keiji Maruyama, Shigekazu Watanabe, Masamichi Goto, Koichi Suzuki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0010672

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https://doi.org/10.1371/journal.pntd.0010672

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