SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production

SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production

In age-related macular degeneration (AMD), one of the principal sources of vascular endothelial growth factor (VEGF) is retinal pigment epithelium (RPE) cells under hypoxia or oxidative stress. Solute carrier family 7 member 11 (SLC7A11), a key component of cystine/glutamate transporter, regulates t...

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Bibliographic Details
Main Authors: Xiaohuan Zhao, Min Gao, Jian Liang, Yuhong Chen, Yimin Wang, Yuwei Wang, Yushu Xiao, Zhenzhen Zhao, Xiaoling Wan, Mei Jiang, Xueting Luo, Feng Wang, Xiaodong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
SLC7A11
RPE
ferroptosis
VEGF
CNV
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.639851/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.639851/full

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