FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver

FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver

Objective: Triglycerides (TGs) associate with apolipoprotein B100 (apoB100) to form very low density lipoproteins (VLDLs) in the liver. The repertoire of factors that facilitate this association is incompletely understood. FITM2, an integral endoplasmic reticulum (ER) protein, was originally discove...

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Bibliographic Details
Main Authors: Haizhen Wang, Cyrus Nikain, Konstantinos I. Fortounas, Jaume Amengual, Ozlem Tufanli, Maxwell La Forest, Yong Yu, Meng C. Wang, Russell Watts, Richard Lehner, Yunping Qiu, Min Cai, Irwin J. Kurland, Ira J. Goldberg, Sujith Rajan, M. Mahmood Hussain, Jeffrey L. Brodsky, Edward A. Fisher
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Metabolism
Subjects:
Liver
VLDL assembly
Triglycerides
Steatosis
ER stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824001790

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http://www.sciencedirect.com/science/article/pii/S2212877824001790

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