Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

The causes of nigrostriatal cell death in idiopathic Parkinson’s disease are unknown, but exposure to toxic chemicals may play some role. We followed up here on suggestions that bacterial secondary metabolites might be selectively cytotoxic to dopaminergic neurons. Extracts from Streptomyces venezue...

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Bibliographic Details
Main Authors: Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Environment International
Subjects:
Dopaminergic neurodegeneration
Streptomyces venezuelae
Bacterial toxin
Ferroptosis
Caenorhabditis elegans
Parkinson’s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412023005020

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http://www.sciencedirect.com/science/article/pii/S0160412023005020

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