HUWE1 Causes an Immune Imbalance in Immune Thrombocytopenic Purpura by Reducing the Number and Function of Treg Cells Through the Ubiquitination Degradation of Ets-1

HUWE1 Causes an Immune Imbalance in Immune Thrombocytopenic Purpura by Reducing the Number and Function of Treg Cells Through the Ubiquitination Degradation of Ets-1

Background: Immune thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder and the decreased number and immunosuppressive dysfunction of Treg cells are key promoters of ITP. However, their mechanisms in ITP development have not been fully clarified.Methods: HUWE1 mRNA and protein levels in...

Full description

Bibliographic Details
Main Authors: Jianqin Li, Yalin Xia, Xiaoru Fan, Xiaofang Wu, Feiyun Yang, Shaoyan Hu, Zhaoyue Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HUWE1
ETS-1
treg cells
immune thrombocytopenic purpura
CD4+
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.708562/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.708562/full

Similar Items