High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires

High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires

Summary: The collection of T cell receptors (TCRs) generated by somatic recombination is large but unknown. We generate large TCR repertoire datasets as a resource to facilitate detailed studies of the role of TCR clonotypes and repertoires in health and disease. We estimate the size of individual h...

Full description

Bibliographic Details
Main Authors: Cinque Soto, Robin G. Bombardi, Morgan Kozhevnikov, Robert S. Sinkovits, Elaine C. Chen, Andre Branchizio, Nurgun Kose, Samuel B. Day, Mark Pilkinton, Madhusudan Gujral, Simon Mallal, James E. Crowe, Jr.
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
adaptive immunity
TCR
CDR3
immune repertoire sequencing
clonotypes
HLA
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308639

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720308639

Similar Items