Immobilization of modular peptides on graphene cocktail for differentiation of human mesenchymal stem cells to hepatic-like cells

Immobilization of modular peptides on graphene cocktail for differentiation of human mesenchymal stem cells to hepatic-like cells

In this study, two novel biomimetic modular peptide motifs based on the alpha-2 subunit of type IV collagen (CO4A2) were designed and immobilized on a graphene platform to imitate integrin and heparan sulfate- (HS-) binding proteins. The in silico study was used to design 9-mer K[KGDRGD]AG and 10-me...

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Bibliographic Details
Main Authors: Behzad Adibi-Motlagh, Ehsan Hashemi, Omid Akhavan, Jafar Khezri, Aram Rezaei, Javad Zamani Amir Zakria, Seyed Davar Siadat, Abbas Sahebghadam Lotfi, Abbas Farmany
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Chemistry
Subjects:
graphene platform
differentiation
hepatic-like cells
in silico
modular peptide
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.943003/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.943003/full

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