Activity of the Lactate Dehydrogenase Inhibitor Oxamic Acid against the Fermentative Bacterium <i>Streptococcus mitis/oralis</i>: Bactericidal Effects and Prevention of Daptomycin Resistance In Vitro and in an Ex Vivo Model
<i>Streptococcus mitis/oralis</i> is a fermentative bacterium that relies on lactate dehydrogenase to balance its redox poise and keep glycolysis active. Metabolomic analysis of an in vitro–derived daptomycin-resistant (DAP-R) <i>S. mitis/oralis</i> strain (351-D10) revealed...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/10/1409 |