Lipid Membrane State Change by Catalytic Protonation and the Implications for Synaptic Transmission

In cholinergic synapses, the neurotransmitter acetylcholine (ACh) is rapidly hydrolyzed by esterases to choline and acetic acid (AH). It is believed that this reaction serves the purpose of deactivating ACh once it has exerted its effect on a receptor protein (AChR). The protons liberated in this re...

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Bibliographic Details
Main Authors: Christian Fillafer, Yana S. Koll, Matthias F. Schneider
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Membranes
Subjects:
Online Access:https://www.mdpi.com/2077-0375/12/1/5