Construction of copy number variation landscape and characterization of associated genes in a Bangladeshi cohort of neurodevelopmental disorders

Construction of copy number variation landscape and characterization of associated genes in a Bangladeshi cohort of neurodevelopmental disorders

Introduction: Copy number variations (CNVs) play a critical role in the pathogenesis of neurodevelopmental disorders (NDD) among children. In this study, we aim to identify clinically relevant CNVs, genes and their phenotypic characteristics in an ethnically underrepresented homogenous population of...

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Main Authors: Hosneara Akter, Muhammad Mizanur Rahman, Shaoli Sarker, Mohammed Basiruzzaman, Md. Mazharul Islam, Md. Atikur Rahaman, Md. Ashiquir Rahaman, Tamannyat Binte Eshaque, Nushrat Jahan Dity, Shouvik Sarker, Md. Robed Amin, Mohammad Monir Hossain, Maksuda Lopa, Nargis Jahan, Shafaat Hossain, Amirul Islam, Ashaduzzaman Mondol, Md Omar Faruk, Narayan Saha, Gopen kumar Kundu, Shayla Imam Kanta, Rezaul Karim Kazal, Kanij Fatema, Md. Ashrafur Rahman, Maruf Hasan, Md. Abid Hossain Mollah, Md. Ismail Hosen, Noushad Karuvantevida, Ghausia Begum, Binte Zehra, Nasna Nassir, A. H. M. Nurun Nabi, K. M. Furkan Uddin, Mohammed Uddin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Genetics
Subjects:
neurodevelopmental disorders (NDDs)
chromosomal microarray analysis (CMA)
copy number variation (CNV)
Autism Diagnostic Observation Schedule-Second Edition (ADOS-2)
variant of uncertain significance (VOUS)
critical exon gene (CEG)
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.955631/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.955631/full

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