NEMO‐Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase‐Induced Lysosome Membrane Permeabilization

NEMO‐Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase‐Induced Lysosome Membrane Permeabilization

Abstract A short peptide termed NEMO‐binding domain (NBD) peptide has an inhibitory effect on nuclear factor kappa‐B (NF‐κB). Despite its efficacy in inhibiting inflammatory responses, the precise neuroprotective mechanisms of NBD peptide in spinal cord injury (SCI) remain unclear. This study aims t...

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Bibliographic Details
Main Authors: Yibo Geng, Junsheng Lou, Junnan Wu, Zhichao Tao, Ningning Yang, Jiaxuan Kuang, Yuzhe Wu, Jiacheng Zhang, Linyi Xiang, Jingwei Shi, Yuepiao Cai, Xiangyang Wang, Jiaoxiang Chen, Jian Xiao, Kailiang Zhou
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
lysosomal membrane permeabilization
NBD peptide
NF‐κB/p38‐MAPK signalling pathway
pyroptosis
spinal cord injury
Online Access:https://doi.org/10.1002/advs.202405759

Internet

https://doi.org/10.1002/advs.202405759

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