Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation

Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation

Abstract Background Idiosyncratic drug-induced liver injury (IDILI) is common in hepatology practices and, in some cases, lethal. Increasing evidence show that tricyclic antidepressants (TCAs) can induce IDILI in clinical applications but the underlying mechanisms are still poorly understood. Method...

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Bibliographic Details
Main Authors: Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Cell Communication and Signaling
Subjects:
NLRP3 inflammasome
Idiosyncratic hepatotoxicity
Antidepressant
Tricyclic antidepressant
Nortriptyline
Online Access:https://doi.org/10.1186/s12964-023-01128-x

Internet

https://doi.org/10.1186/s12964-023-01128-x

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