The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndrome

The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndrome

Abstract While post mortem studies have identified the major cell types and functional systems affected in Alzheimer’s disease (AD) the initial sites and molecular characteristics of pathology are still unclear. Because individuals with Down syndrome (DS) (trisomy 21) develop the full pathological c...

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Bibliographic Details
Main Authors: Yvonne S. Davidson, Andrew Robinson, Vee P. Prasher, David M. A. Mann
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Down syndrome
Amyloid
Tau
Online Access:http://link.springer.com/article/10.1186/s40478-018-0559-4

Internet

http://link.springer.com/article/10.1186/s40478-018-0559-4

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