CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair

CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair

CtIP is involved in the resection of broken DNA during the S and G2 phases of the cell cycle for repair by recombination. Acting with the MRN complex, it plays a particularly important role in handling complex DNA end structures by localised nucleolytic processing of DNA termini in preparation for l...

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Bibliographic Details
Main Authors: Oliver J Wilkinson, Alejandro Martín-González, Haejoo Kang, Sarah J Northall, Dale B Wigley, Fernando Moreno-Herrero, Mark Simon Dillingham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
homologous recombination
Sae2
DNA end resection
atomic force microscopy
DNA repair
double-stranded DNA break repair
Online Access:https://elifesciences.org/articles/42129

Internet

https://elifesciences.org/articles/42129

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