Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In th...
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| Format: | Article |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2021.781098/full |
| _version_ | 1818691138499903488 |
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| author | Shuo-Qi Zhang Shuo-Qi Zhang Jun Xiao Man Chen Luo-Qi Zhou Ke Shang Chuan Qin Dai-Shi Tian |
| author_facet | Shuo-Qi Zhang Shuo-Qi Zhang Jun Xiao Man Chen Luo-Qi Zhou Ke Shang Chuan Qin Dai-Shi Tian |
| author_sort | Shuo-Qi Zhang |
| collection | DOAJ |
| description | Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In this article, we will review the current knowledge of the role of S1P signaling in brain ischemia from the aspects of inflammation and immune interventions, sustaining endothelial functions, regulation of blood-brain barrier integrity, and functional recovery. We will then discuss the current and future therapeutic perspectives of targeting S1P for the treatment of ischemic stroke. Mechanism studies would help to bridge the gap between preclinical studies and clinical practice. Future success of bench-to-bedside translation shall be based on in depth understanding of S1P signaling during stroke and on the ability to have a fine temporal and spatial regulation of the signal pathway. |
| first_indexed | 2024-12-17T12:37:08Z |
| format | Article |
| id | doaj.art-9910cb777bb346ada2f1b6f23b2b6835 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-17T12:37:08Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-9910cb777bb346ada2f1b6f23b2b68352022-12-21T21:48:14ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022021-11-011510.3389/fncel.2021.781098781098Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and BeyondShuo-Qi Zhang0Shuo-Qi Zhang1Jun Xiao2Man Chen3Luo-Qi Zhou4Ke Shang5Chuan Qin6Dai-Shi Tian7Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In this article, we will review the current knowledge of the role of S1P signaling in brain ischemia from the aspects of inflammation and immune interventions, sustaining endothelial functions, regulation of blood-brain barrier integrity, and functional recovery. We will then discuss the current and future therapeutic perspectives of targeting S1P for the treatment of ischemic stroke. Mechanism studies would help to bridge the gap between preclinical studies and clinical practice. Future success of bench-to-bedside translation shall be based on in depth understanding of S1P signaling during stroke and on the ability to have a fine temporal and spatial regulation of the signal pathway.https://www.frontiersin.org/articles/10.3389/fncel.2021.781098/fullsphingosine-1-phosphateischemic strokefingolimodneuroprotective agenttranslational research |
| spellingShingle | Shuo-Qi Zhang Shuo-Qi Zhang Jun Xiao Man Chen Luo-Qi Zhou Ke Shang Chuan Qin Dai-Shi Tian Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond Frontiers in Cellular Neuroscience sphingosine-1-phosphate ischemic stroke fingolimod neuroprotective agent translational research |
| title | Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
| title_full | Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
| title_fullStr | Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
| title_full_unstemmed | Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
| title_short | Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond |
| title_sort | sphingosine 1 phosphate signaling in ischemic stroke from bench to bedside and beyond |
| topic | sphingosine-1-phosphate ischemic stroke fingolimod neuroprotective agent translational research |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2021.781098/full |
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