Clonality Analysis for the Relationship between the Pulmonary Combined Neuroendocrine Carcinoma and “the So-Called Reported Histologic Transformation”

Clonality Analysis for the Relationship between the Pulmonary Combined Neuroendocrine Carcinoma and “the So-Called Reported Histologic Transformation”

Histologic transformation (HT) is common following targeted therapy in adenocarcinoma. However, whether the transformed tumor is a new component or a combined neuroendocrine carcinoma (C-NEC) remains controversial. We aimed to explore the relationship between pulmonary C-NEC and HT. Macro-dissection...

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Bibliographic Details
Main Authors: Haiyue Wang, Yanli Zhu, Wei Sun, Xin Yang, Xinying Liu, Kaiwen Chi, Xiaozheng Huang, Lixin Zhou, Weijing Cai, Dongmei Lin
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cancers
Subjects:
combined neuroendocrine carcinoma
histologic transformation
whole exome sequencing
clonality analysis
immunohistochemistry
RB1
Online Access:https://www.mdpi.com/2072-6694/15/23/5649

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https://www.mdpi.com/2072-6694/15/23/5649

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