CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via phosphatase MKP-1-dependent inhibition of ERK.

CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via phosphatase MKP-1-dependent inhibition of ERK.

Nontypeable Haemophilus influenzae (NTHi), a Gram-negative bacterium, is the primary cause of otitis media in children and the exacerbation of chronic obstructive pulmonary disease in adults. A hallmark of both diseases is an overactive inflammatory response, including the upregulation of chemokines...

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Bibliographic Details
Main Authors: Wenzhuo Y Wang, Kensei Komatsu, Yuxian Huang, Jing Wu, Wenhong Zhang, Ji-Yun Lee, Masanori Miyata, Haidong Xu, Jian-Dong Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4229244?pdf=render

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http://europepmc.org/articles/PMC4229244?pdf=render

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